Differences

This shows you the differences between two versions of the page.

--- start [2025/02/21 09:26] – gilbert
+++ start [2025/03/05 15:24] (current) – admin
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 ====== PDL1 in one nutshell ======
+[[Triaging PDL1 3D requests]]
 ===== What is PDL1? =====
 Programmed death-ligand 1 is a protein that in humans is encoded by the CD274 gene. It is a transmembrane protein that **suppresses** the [[Cellular Immunity|cellular immunity]] during particular events such as physiological event like pregnancy, physiopathological event like protecting normal cells in context of infection/inflammation and to prevent autoimmune disease. Cellular immunity is most effective against cells infected with viruses, intracellular bacteria, fungi and protozoans. Malignant cells also take advantage of this protective mechanism to escape immunne surveillance.  The [[keynote001|2015 revolution in immunotherapy]] is based on preventing cancer to escape immune surveillance by inhibiting interaction between **PD1** (expressed by CD8) and **PDL1** (expressed by tumoural cells) using an engineered humanized IgG4 antibody targeting either PD1 or PDL1.
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 **In the upper right picture, two humanized antibodies IgG4 anti-PD1 and anti-PDL1 are respectively represented by a red triangle and an incomplete yellow circle
 **
-===== Triaging PDL1 requests =====
 ===== Can I use any PDL1 for any type of tumour? =====
 **No**. There is no agnostic PDL1 assessment and predicting response to therapy relies on clinical trials which developed a specific PDL1 test for a specific drug and a specific cancer summarized as the 3D concept below.