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--- tps-cps [2023/04/23 12:00] – admin
+++ tps-cps [2025/02/01 17:00] (current) – external edit 127.0.0.1
@@ Line 8: / Line 8: @@
 CPS and TPS are quite different in their approaches. Regarding the assessment TPS, one challenge is the detection of weakly stained tumoural cells. Sometimes a subset will be strongly positive and can sidetrack our focus from another weakly stained subset. Immune cells must be ignored in the TPS assessment and sometimes macrophages mimic tumoral cells and one has to review the associated H&E. CPS has different challenge. While TPS can be estimated from visual assessment of stained vs non-stained proportions, this is not possible for CPS. Indeed the "area" of immune positive cells and the "area" of tumour are de-correlated in term of cellularity.
 {{ ::cpstpschallenges.jpg?nolink |}}
+Assessing either TPS and CPS is not straightforward. Different scenario are encountered which trigger different strategies to properly assessed this PDL1 biomarker. Here are examples of scenario
+{{ ::tps-cps-scenario.jpg?nolink |}}
 Estimating the number of cells in a microscopic field is not easy as demonstrated below (it represents a picture of breast cancer with some weakly ER positive nuclei). An open source software developed with [[https://imagej.net/software/fiji/|FIJI]] is available to estimate the number of cells from a picture taken from your camera. A video is available to explain how to use it. https://github.com/gilbertbigras/PDL1-CPS-Denominator.